Vitamin E interactions with other nutrients

Vitamin E exerts antioxidant effects in combination with other antioxidants including beta carotene, vitamin C and selenium. Vitamin C can restore oxidized vitamin E to its natural antioxidant form. Megadoses of vitamin C may increase vitamin E requirements. Vitamin E can also protect against some of the effects of excessive vitamin A and regulates levels of that vitamin. Vitamin E is necessary for the action of vitamin A and high intake of vitamin A may decrease vitamin E absorption

Vitamin E interactionsVitamin E may be necessary for the conversion of vitamin B12 to its active form and may reduce some of the symptoms of zinc deficiency. Large doses of vitamin E may interfere with the anticoagulant action of vitamin K and may reduce intestinal absorption of vitamin K. Inorganic iron destroys vitamin E, so the two supplements should not be taken together.

Vitamin E interactions with drugs

Cholestyramine, mineral oil and alcohol may reduce the absorption of vitamin E from the intestine. Vitamin E can enhance the action of anticoagulant drugs on blood clotting and should not be taken in large doses. However, the results of a 1996 study in which 21 people taking chronic warfarin therapy received either vitamin E or placebo suggest that vitamin E can safely be given to patients who require chronic warfarin therapy.


Vitamin E should be used cautiously by anyone with an overactive thyroid or rheumatic heart disease. Vitamin E in large doses may aggravate iron deficiency anemia. Vitamin E supplements can cause a transient rise in blood pressure and should be used with caution by anyone suffering from hypertension.

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Other Vitamins:

Vitamin A
Beta carotene
Vitamin B6
Vitamin B12
Pantothenic acid
Vitamin C
Vitamin D
Vitamin E
Vitamin K