Vitamin E 200

Vitamin E 200 supplements are used to treat deficiency and to prevent it in those at risk. Supplements are also used in a wide range of disorders where there is an increased need for immune support and protection against free radical damage. A study published in 1996 by researchers from the National Institute on Aging examined the effects of vitamin E and vitamin C supplement on mortality risk in 11,178 persons aged from 67 to 105 who were taking part in the Established Populations for Epidemiologic Studies of the Elderly Study. From 1984 through 1993 there were 3490 deaths. The results showed that those using the Vitamin E 200 supplements had a 34 per cent lower risk of death when compared to those not using vitamin E supplements, and around half the risk of death from coronary disease.

Vitamin E 200Cardiovascular disease

Several studies have shown that high vitamin E intake can reduce the risk of developing heart disease and improve the symptoms in those who do have the disease. Results from the Nurses Health Study provide evidence for the protective effects of vitamin E. Results published in 1993 assessed the links between vitamin E and heart disease in 87,245 female nurses aged from 34 to 59 who were free of diagnosed cardiovascular disease and cancer in 1980. During the follow-up period of eight years, there were 552 cases of major coronary disease (437 nonfatal heart attacks and 115 deaths due to coronary disease). The results showed that women with the highest vitamin E intakes had 34 per cent less risk of major coronary disease compared to those with the lowest intakes. Most of the reduction in risk was attributable to vitamin E consumed as supplements, a finding which conflicts with some other studies which only show benefit from high dietary intakes. Women who took Vitamin E 200 supplements for short periods had little apparent benefit, but those who took them for more than two years had an even lower risk of disease.

Results from a British study known as the Cambridge Heart Antioxidant Study (CHAOS) which were published in The Lancet in 1996 provide further evidence of a link between vitamin E supplements and reduction in heart disease risk. In this double-blind, placebo-controlled study, 2002 patients with coronary atherosclerosis were enrolled and followed up for 510 days. 546 patients were given 536 mg (800 IU) daily; 589 were given 268 mg (400 IU) per day and 967 received identical placebo capsules. The results showed that in the group who received vitamin E supplements, there was a 75 per cent reduction in the risk of non-fatal heart attacks. The beneficial effects were apparent after one year of treatment.

As part of the Finnish Alpha-Tocopherol, Beta carotene Cancer (ATBC) Prevention Study, researchers studied the preventive effect of vitamin E and beta carotene supplements on major coronary events. A total of 27,271 Finnish male smokers aged 50 to 69 years with no history of heart attack were randomly assigned to receive 50 mg (75 IU) and a 20 mg dose of beta carotene, both supplements, or placebo daily for five to eight years. During this period there were 1204 nonfatal heart attacks and 907 fatal ones. The results showed that major coronary events decreased 4 per cent among those taking Vitamin E 200. Supplementation with vitamin E also decreased the incidence of fatal coronary heart disease by 8 per cent although did not appear to affect the incidence of nonfatal heart attacks. The dose of vitamin E used in this study is smaller than that commonly used.

Vitamin E may help prevent heart disease in a number of ways. It lowers total blood cholesterol levels, and as it is easily incorporated into the harmful LDL cholesterol molecule, it can protect it from oxidation by free radicals. Oxidized LDL cholesterol is more likely to block arteries and contribute to the atherosclerotic process than unoxidised LDL cholesterol. Vitamin E may be able to prevent the free radical damage that occurs when blood is cut off then re-supplied, for example during surgery or in the case of a blood vessel spasm. Vitamin E also has important direct effects on vascular endothelial and smooth muscle cells and also inhibits the clumping together of platelets which helps to reduce atherosclerotic plaque formation. It also seems to inhibit the attachment of white blood cells to artery linings which is caused by LDL cholesterol.

A study published in 1996 suggests that the minimum dose of supplementary vitamin E which will significantly reduce the susceptibility of LDL to oxidation is 335 mg (500 IU) per day.


Vitamin E appears to play a part in decreasing the risk of angina. Results of the Finnish ATBC Prevention Study found a slightly reduced risk in those taking vitamin E supplements.


Vitamin E supplements, especially when combined with selenium, have shown beneficial effects in the prevention of certain types of cancer, including breast cancer. Results from the US National Institute on Aging study mentioned above showed a 22 per cent decrease in the risk of death from cancer in those taking Vitamin E 200 supplements.

Vitamin E may protect against cell membrane and chromosome damage that would otherwise lead to cancerous changes in cells. Vitamin E also inhibits the growth of abnormal cells and plays a role in their conversion back to normal cells. Vitamin E can also prevent the formation of certain carcinogens by combining with substances in the intestine. For example, the formation of cancer- causing nitrosamines from dietary nitrites in the stomach may be inhibited by vitamin E.

Vitamin E 200Prostate cancer

According to more results from the ATBC study published in 1998 in the Journal of the National Cancer Institute, vitamin E reduces the risk of prostate cancer among smokers. Researchers studied the effects of 50 mg (75 IU) in Finnish men and the results showed a 32 per cent decrease in the incidence of prostate cancer and a 41 per cent decrease in prostate cancer deaths among the men taking vitamin E, compared with those who took no vitamin E.


High doses of vitamin E boost the immune system in elderly people. In a 1997 study of 88 healthy people, aged 65 or older, those who took 200 mg (300 IU) each day for about four months showed an improvement in immune response. Researchers assessed the effects of either 60 mg (90 IU), 200 mg (300 IU) or 800 mg (1333) on a measure of immune system strength known as delayed hypersensitivity skin response. The results showed that those who took 200 mg a day had a 65 per cent increase in immune function. Those taking 60 mg or 800 mg of vitamin E also showed some improvements in immune function but the ideal response was seen in those taking 200 mg. In other tests, those who took the supplements produced six times more antibodies to hepatitis B after being given the vaccine than those who took placebo. They also produced more antibodies against tetanus infection. The study, which was reported in the Journal of the American Medical Association provides more support for vitamin E supplementation in older people.


Vitamin E may also help to slow disease progression in HIV-positive people. The results of a nine year study involving 311 HIV-positive men showed that those patients with the highest vitamin E intakes had a 35 per cent decrease in risk of progression to AIDS when compared to those in the lowest intake group.


Vitamin E may improve insulin action in some diabetics. Those with the disorder are particularly susceptible to oxidative damage and vitamin E may play a role in preventing the long-term complications of diabetes. Studies show that vitamin E can protect diabetics against LDL cholesterol oxidation and other adverse effects of the disease.

In a study published in 1996, Louisiana researchers examined whether 67 mg (100 IU) per day had any effect on blood lipid oxidation products and blood lipid profiles of 35 diabetic patients over a three month period. The results showed that vitamin E supplementation significantly lowered lipid peroxidation products and lipid levels in diabetic patients.

Type I diabetes

The results of a 1997 study done in Italy show that vitamin E can protect against damage to beta cells which produce insulin in Type I diabetes patients. The one year study involved 84 patients between 5 and 35 years of age. One group was treated with vitamin E supplements and the other group received nicotinic acid which has been shown to protect pancreatic beta cell function (See page 80 for more information.) All patients were under intensive insulin therapy with three to four injections a day. The results showed that vitamin E was as effective as nicotinic acid in protecting the beta cells.


Vitamin E supplements may help to prevent cataract progression, according to a 1998 study published in the journal Ophthalmology. Researchers found that among a group of around 750 elderly people, those who took vitamin E supplements had half the risk that their cataracts would progress over a four- and-a-half-year period. Taking a multivitamin pill lowered the risk by one-third.


Animal studies suggest that moderate doses of vitamin E may enhance the ability of sperm to fertilize eggs. Recent studies suggest that vitamin E supplements may be useful in treating male infertility by improving sperm function.


Vitamin E has anti-inflammatory and analgesic activity which may be useful in rheumatoid arthritis patients. In a study published in 1997, UK researchers treated 42 patients with 600 mg (895 IU) twice a day or with placebo for 12 weeks. The patients were already receiving anti-rheumatic drug treatment. Laboratory and clinical measures of inflammation were not influenced by the treatment. However, the pain measures; including pain in the morning, pain in the evening, and pain after chosen activity; were significantly decreased after vitamin E treatment when compared with placebo.


Antioxidants may help asthmatics. According to researchers at the University of Washington, antioxidant vitamin supplements may help relieve the symptoms of asthma. The researchers measured the amount of breath expelled by the lungs in 17 asthma sufferers. The subjects took peak flow lung function tests while running on a treadmill and breathing in high levels of polluted air. In those asthmatics whose diets were supplemented with daily doses of 268 mg (400 IU) and 500 mg of vitamin C, an 18 per cent increase in peak flow capacity was seen.

Alzheimer's disease

Vitamin E may slow the progression of Alzheimer's disease. Researchers at Columbia University have found that treatment with vitamin E slows the progression of Alzheimer's disease symptoms. In a study reported in 1997 in the New England Journal of Medicine, patients were treated with 1340 mg (2000 IU) daily, 10 mg of selegiline daily, a combination of the two, or a placebo for two years. The patients were monitored every three months by the researchers who looked for signs such as the loss of ability to perform basic activities, institutionalization or severe dementia. Researchers found that all the treatment groups had delayed rate of loss of function when compared with the placebo group.

Vitamin E 200Liver disorders

Vitamin E levels have been found to be low in patients with liver damage and supplements have been shown to protect against liver damage induced by oxidative stress in animal experiments. In a 1997 German study, researchers treated 23 hepatitis C patients with two 268 mg (400 IU) doses per day for 12 weeks. In 11 of 23 patients, the measurements in clinical tests to assess liver damage showed improvement during Vitamin E 200 treatment.

Hot flashes

In a study published in 1998, researchers at the Mayo Clinic in Minnesota looked at the effect of vitamin E on hot flashes in 104 women who had survived breast

cancer. The women were experiencing at least two hot flashes per day. The study took nine weeks. In weeks two to five, the women took either vitamin E 200 or a placebo and in weeks six to nine, they took the alternative pill. The results showed that in general, women taking vitamin E experienced approximately one less hot flash per day than women taking the placebo.


A growing amount of evidence indicates that free radicals play an important role in causing skeletal muscle damage and inflammation after strenuous exercise. The generation of oxygen-free radicals may be increased during exercise as a result of increases in oxygen metabolism in the energy producing organelles of the cell - the mitochondria. These changes may lead to damage to cholesterol and DNA. Increased antioxidant activity can help to prevent this damage and some research suggests that antioxidant vitamin supplementation can be protective in people who regularly exercise heavily.

In a study published in 1998, Pennsylvania State University researchers investigated the effects of high intensity resistance exercise on free radical production and also whether vitamin E supplementation could affect free radical formation or muscle membrane disruption. They divided 12 weight-trained males into two groups. The supplement group received 804 mg (1200 IU) once a day for a period of two weeks and the other group received a placebo. The results showed that high intensity resistance exercise increased free radical production and that vitamin E supplementation decreased muscle membrane disruption.

Other uses

Vitamin E 200 has been used to bring relief from the fibrocystic breast changes which are usually part of the premenstrual syndrome and are considered a risk factor for breast cancer. Some evidence suggests that vitamin E may also help prevent scarring and decrease wound-healing time. Vitamin E has also been used to treat inflammatory bowel disease, periodontal disease and gout due to its antioxidant and anti-inflammatory properties.

Long-term antipsychotic drug use causes nervous system side effects such as involuntary movements of the face and mouth. Vitamin E 200 has been successfully used to treat these side effects.

Pre-treatment with vitamin E may help to stop the adverse effects of surgery on skeletal muscles. When blood is reperfused into muscle after a period of stoppage, oxidative damage tends to occur; and as an antioxidant, vitamin E is effective in reducing this damage.

Anticonvulsants such as phenobarbital, phenytoin and carbamazepine may lower plasma vitamin E levels by altering absorption, distribution and metabolism. Isoniazid also decreases vitamin E absorption. Neomycin impairs utilization of vitamin E.

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Other Vitamins:

Vitamin A
Beta carotene
Vitamin B6
Vitamin B12
Pantothenic acid
Vitamin C
Vitamin D
Vitamin E
Vitamin K