Niacin interactions with other nutrients

Vitamin B6, riboflavin and iron are necessary for the conversion of tryptophan to niacin. Niacin works with other B vitamins to perform its functions in the body. The amino acid, leucine, competes with tryptophan for absorption and diets low in niacin and high in leucine may lead to niacin deficiency disease. Niacin may also enhance the utilization of zinc and iron.

Niacin interactions with drugs

Niacin may reduce the toxic side effects on heart tissue of the anticancer drug adriamycin without reducing its effectiveness in the treatment of cancer. It may also enhance the effectiveness of anticonvulsant drugs such as phenobarbital. Antibiotics may cause niacin flushes to become more severe.
Niacin interactions The drug isoniazid, may cause niacin deficiency disease as it reduces the conversion of tryptophan to niacin. Oral contraceptives appear to increase the conversion efficiency of tryptophan to niacin.

Alcohol may increase niacin needs and nicotinamide has been shown to protect against the damage to liver cells caused by drinking a large quantity of alcohol.

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