Folate interactions with other nutrients

Folic acid requires vitamin B12, niacin and vitamin C to be converted to its biologically active form. Vitamin C helps to reduce folic acid excretion. High folic acid intakes may reduce zinc absorption, although the effect is likely to be a subtle one.

Folate interactions with drugs

NSAIDs such as aspirin, ibuprofen and acetaminophen can increase folate requirements if taken for long periods. Anticonvulsant drugs such as phenytoin and phenobarbital also raise folate requirements which may be of particular concern as these drugs are often taken for long periods.
Methotrexate increases requirements and it is recommended that people taking this drug for long periods also take folic acid supplements. Cholestyramine, chloramphenicol, estrogen, colchicine, antacids, antituberculosis drugs, trimethoprim, sulfasalazine, corticosteroid drugs and tobacco can raise folic acid requirements. Chronic alcohol use leads to folic acid deficiency.

Folate Categories:

Folate
Folate health
Folate absorption
Folate deficiency
Folate sources
Folate recommended daily
Folate overdose
Folate supplements
Folate pregnancy
Folate interactions

Other Vitamins:

Vitamin A
Carotenes
Beta carotene
Lycopene
Lutein
Thiamin
Riboflavin
Niacin
Vitamin B6
Folate
Vitamin B12
Biotin
Pantothenic acid
Vitamin C
Vitamin D
Vitamin E
Vitamin K