Coenzyme Q10 interactions with other nutrients

Coenzyme Q10 synthesis requires vitamins B6, C, B12, folic acid, riboflavin, niacin, and pantothenic acid.

Coenzyme Q10 interactions with drugs

Several different types of medications have side effects that include adverse effects on heart function. Some of these drugs, such as doxorubicin, have effects on the heart that are so severe that the amount of time for which they can be used is strictly limited. Research has shown that the toxic effect of doxorubicin is due to its inhibitory effects on coenzyme QlO-dependent enzyme systems. Coenzyme Q10 reduces the toxic effects of doxorubicin on the heart.

Coenzyme Q10 interactionsAnother class of drugs, known as beta blockers, which are used to treat high blood pressure and some other types of cardiovascular disease, have been shown to interfere with the production and function of coenzyme Q10, and to adversely affect heart function. This may explain why, in some cases, long- term therapy with beta blockers can lead to congestive heart failure. Coenzyme Q10 therapy in combination with beta blockers may be beneficial.

In recent years, the drugs lovastatin, pravastatin, and simvastatin have become widely used to treat high blood cholesterol. These medications work by inhibiting an enzyme known as HMG-CoA reductase, and they are verv effective in toweling cholesterol levels. How ever, this enzyme is also responsible for production of coenzyme Q10. Because of this, the cholesterol-lowering effect of these drugs is accompanied by an equivalent lowering of coenzyme Q10 levels.In patients with existing heart failure, lovastatin has been shown to cause increased heart disease with life-threatening results in some patients. Coenzyme Q10 supplements may help to prevent some of the adverse effects of these widely used drugs.

Others drugs, such as phenothiazine neuroleptics and tricyclic antidepressants, also have effects on heart function which seem to be related to inhibition of coenzyme Q10 function.

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Other Nutrients:

Essential fatty acids
Para-aminobenzoic acid
Pangamic acid
Coenzyme Q10
Amino acids
Lipoic acid
Shark cartilage
Digestive support
Betaine hydrochloride
Digestive enzymes
Fiber supplements