Choline supplements, Therapeutic uses of Choline supplements

Choline supplements have been used to treat the symptoms of brain diseases such as Alzheimer's disease and Huntington's chorea, in which acetylcholine levels are low due to the reduced activity of the enzyme which synthesizes it. Some studies have detected improvements in mental performance after choline treatment. However, results of studies have been mixed. Choline and lecithin may only be useful in the initial stages of the disease. In a 1994 study, lecithin was given to patients with Alzheimer's disease in daily doses of 1000 mg for one month. Results showed slightly improved mental performance, and enhanced cerebrovascular blood flow.

Choline supplementsCardiovascular disease

Choline helps to lower cholesterol levels, as a choline-containing enzyme helps to remove cholesterol from tissues. In a 1995 study, researchers gave lecithin supplements to 32 patients with high cholesterol and triglyceride levels. The dosage used was 3.5 g three times daily before meals. After 30 days of treatment, total cholesterol and triglycerides levels decreased significantly, and beneficial HDL cholesterol levels rose. Choline has also been used to lower homocysteine concentrations, another risk factor for cardiovascular disease.

Other uses

Choline supplements (in the form of lecithin) have been shown to bring some benefits in the treatment of bipolar disorder (manic depression). Choline and lecithin are also used to treat liver damage and hepatitis. Supplements have also been used to treat asthma.


Severe folic acid deficiency causes secondary liver choline deficiency, and vice versa, in rats. Choline supplements reduce urinary excretion of carnitine.

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Choline supplements



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